产品名称

CC-885

产品货号

Axon 2645 CAS [1010100-07-8] MF C22H21ClN4O4MW 440.88 Purity: 99% Soluble in DMSO Description Cereblon (CRBN) modulator with potent anti-tumour activity which is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. CC-885 exhibits potent anti-proliferative activity in patient-derived acute myeloid leukaemia (AML) tumour cell lines. KEYWORDS: CC-885 | supplier | Cereblon (CRBN) modulator | CC885 | CAS [1010100-07-8] | Ubitquitin | signaling | E3 ligase | GSPT1 | CRL4 | DDB1 | CUL4 | AML | myeloid leukaemia

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

CC-885

Based on 2 reference(s) in Google Scholar 10 10 2

Axon 2645

CAS [1010100-07-8]

MF C22H21ClN4O4
MW 440.88

Purity: 99%
Soluble in DMSO

CC-885

Description

Cereblon (CRBN) modulator with potent anti-tumour activity which is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. CC-885 exhibits potent anti-proliferative activity in patient-derived acute myeloid leukaemia (AML) tumour cell lines.

KEYWORDS: CC-885 | supplier | Cereblon (CRBN) modulator | CC885 | CAS [1010100-07-8] | Ubitquitin | signaling | E3 ligase | GSPT1 | CRL4 | DDB1 | CUL4 | AML | myeloid leukaemia

T Ito et al. Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs. Int J Hematol. 2016 Sep;104(3):293-9.

ME Matyskiela et al. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature. 2016 Jul 14;535(7611):252-7.

Cereblon (CRBN) modulator with potent anti-tumour activity

Chemical name

1-(3-chloro-4-methylphenyl)-3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)urea

Parent CAS No.

[1010100-07-8]

产品资料