产品名称

iMDK

产品货号

Axon 2258 CAS [881970-80-5] MF C21H13FN2O2SMW 376.40 Purity: 99% Soluble in DMSO Description MDK expression inhibitor; iMDK inhibits specifically and dose-dependently the expression of Midkine (MDK) in H441 lung adenocarcinoma cells, but does not inhibit PTN (Pleiotrophin), which has considerable homology to MDK. iMDK induces apoptotosis in MDK-expressing H441 lung adenocarcinoma cells by suppression of the PI3K/Akt pathway but not the MAPK pathway. iMDK does not inhibit another growth factor VEGF. KEYWORDS: iMDK | Midkine expression inhibitor | CAS [881970-80-5] | NF-κB Pathway | Midkine | Inhibitor | Proteins | cytokine | NF-êB | PI3K | Akt | Apoptosis | Carcinoma | Lung cancer

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

iMDK

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2258

CAS [881970-80-5]

MF C21H13FN2O2S
MW 376.40

Purity: 99%
Soluble in DMSO

iMDK

Description

MDK expression inhibitor; iMDK inhibits specifically and dose-dependently the expression of Midkine (MDK) in H441 lung adenocarcinoma cells, but does not inhibit PTN (Pleiotrophin), which has considerable homology to MDK. iMDK induces apoptotosis in MDK-expressing H441 lung adenocarcinoma cells by suppression of the PI3K/Akt pathway but not the MAPK pathway. iMDK does not inhibit another growth factor VEGF.

H. Hao et al. Inhibition of the growth factor MDK/midkine by a novel small molecule compound to treat non-small cell lung cancer. PLoS One. 2013, 8, e71093.

Apoptosis Cardiovascular Cell Signaling & Oncology Diabetes & Metabolism Pain & Inflammation NF-κB PI3K-Akt-mTOR Midkine Cytokine

Specific inhibitor of Midkine (MDK) expression

Chemical name

3-(2-(4-fluorobenzyl)imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one

Parent CAS No.

[881970-80-5]

产品资料