产品名称

ASB14780

产品货号

Axon 2578 CAS [1069046-00-9] MF C31H27NO3.C4H11NO3MW 582.69 Purity: 99% Soluble in DMSO Description Potent, orally available inhibitor of cytosolic phospholipase A2α (cPLA2α, a group IVA phospholipase A2, aka IVA-PLA2) with an IC50 value 0.020 µM in vitro and 0.54 - 0.64 µM in whole blood assay (guinea pig and human, respectively)) with anti-inflammatory efficacy in ear edema and asthma models, and potentially useful for the treatment of nonalcoholic fatty liver diseases, including fatty liver and hepatic fibrosis. ASB14780 markedly attenuated expression of smooth muscle a-actin (a-SMA) protein and the mRNA expression of collagen 1a2, a-SMA, and TGFb1 in the liver, and inhibited the expression of monocyte/macrophage markers. Sold as tromethamine (THAM) salt, as it was used in original publication. KEYWORDS: ASB14780 | supplier | cPLA2α inhibitor | ASB-14780 | CAS [1069046-00-9] | [1069044-40-1] | Phospholipids | cPLA2 | phospholipase | anti-inflammatory | edema | asthma | pulmonary diseases | fatty liver diseases | hepatic fibrosis | actin | collagen | TGFb1

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

ASB14780

Based on 11 reference(s) in Google Scholar 8 10 11

Axon 2578

CAS [1069046-00-9]

MF C31H27NO3.C4H11NO3
MW 582.69

Purity: 99%
Soluble in DMSO

ASB14780

Description

Potent, orally available inhibitor of cytosolic phospholipase A2α (cPLA2α, a group IVA phospholipase A2, aka IVA-PLA2) with an IC50 value 0.020 µM in vitro and 0.54 - 0.64 µM in whole blood assay (guinea pig and human, respectively)) with anti-inflammatory efficacy in ear edema and asthma models, and potentially useful for the treatment of nonalcoholic fatty liver diseases, including fatty liver and hepatic fibrosis. ASB14780 markedly attenuated expression of smooth muscle a-actin (a-SMA) protein and the mRNA expression of collagen 1a2, a-SMA, and TGFb1 in the liver, and inhibited the expression of monocyte/macrophage markers. Sold as tromethamine (THAM) salt, as it was used in original publication.

T Tomoo et al. Design, synthesis, and biological evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2α inhibitors. J Med Chem. 2014 Sep 11;57(17):7244-62.

S Kanai et al. ASB14780, an Orally Active Inhibitor of Group IVA Phospholipase A2, Is a Pharmacotherapeutic Candidate for Nonalcoholic Fatty Liver Disease. J Pharmacol Exp Ther. 2016 Mar;356(3):604-14.

Potent, orally available inhibitor of cPLA2α; antiinflammatory drug

Chemical name

3-(3-Phenethyl-1-(4-phenoxyphenyl)-1H-indol-5-yl)propanoic acid tris salt

Parent CAS No.

[1069044-40-1]

产品资料