| 产品名称 | EVP 4593 |
| 产品货号 | Axon 2080 CAS [545380-34-5] MF C22H20N4OMW 356.42 Purity: 99% Soluble in DMSO Description Potent NF-κB activation inhibitor (EC50: 9 nM); inhibits SOC pathway in HD neurons; exerts neuroprotective effects in transgenic HD flies and transgenic HD mouse neurons. EVP4593 was not active when tested in the IKK kinase assay References Certificates Categories Extra info J Wu et al. Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment. Chem. Biol. 2011, 18(6), 777-793. M Tobe et al. A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives. Bioorg. Med. Chem. 2003, 11, 3869–3878. Certificate of Analysis Material Safety Data Sheet Cardiovascular Cell Signaling & Oncology CNS Immunology Pain & Inflammation Transcription Factors NF-κB L-Type NF-κB NF-κB activation inhibitor; inhibits SOC pathway Chemical name N4-(4-phenoxyphenethyl)quinazoline-4,6-diamine Parent CAS No. [545380-34-5] Order Size Unit Price Stock 10 mg €110.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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EVP 4593Axon 2080 CAS [545380-34-5] MF C22H20N4O
Description
Potent NF-κB activation inhibitor (EC50: 9 nM); inhibits SOC pathway in HD neurons; exerts neuroprotective effects in transgenic HD flies and transgenic HD mouse neurons. EVP4593 was not active when tested in the IKK kinase assay
NF-κB activation inhibitor; inhibits SOC pathway
Chemical nameN4-(4-phenoxyphenethyl)quinazoline-4,6-diamine Parent CAS No.[545380-34-5] |
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