产品名称

GSK 2033

产品货号

Axon 2363 CAS [1221277-90-2] MF C29H28F3NO5S2MW 591.66 Purity: 100% Soluble in DMSO Description The first potent cell-active LXR antagonist (IC50 value 31.6 nM for LXRβ binding). In intact cells stimulated with LXR agonist, GSK 2033 showed a dose-dependent reduction in the expression of the ATP-binding cassette transporter A1 (ABCA1) in THP-1 cells and SREBP-1c in HepG2 cells. A useful chemical probe to explore the cell biology of the LXR receptor. KEYWORDS: GSK 2033 | supplier | LXR antagonist | GSK2033 | CAS [1221277-90-2] | Metabolism | LXR | Agonist | ATP-binding cassette transporter A1 | ABCA1 | nuclear receptor | NR | lipid | homeostasis | cholesterol

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

GSK 2033

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2363

CAS [1221277-90-2]

MF C29H28F3NO5S2
MW 591.66

Purity: 100%
Soluble in DMSO

GSK 2033

Description

The first potent cell-active LXR antagonist (IC50 value 31.6 nM for LXRβ binding). In intact cells stimulated with LXR agonist, GSK 2033 showed a dose-dependent reduction in the expression of the ATP-binding cassette transporter A1 (ABCA1) in THP-1 cells and SREBP-1c in HepG2 cells. A useful chemical probe to explore the cell biology of the LXR receptor.

W.J. Zuercher et al. Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J. Med. Chem. 2010, 53, 3412-3416.

L.A. Solt et al. LXR-mediated inhibition of CD4+ T helper cells. PLoS One. 2012, 7, e46615.

The first potent cell-active LXR antagonist

Chemical name

2,4,6-trimethyl-N-((3'-(methylsulfonyl)biphenyl-4-yl)methyl)-N-((5-(trifluoromethyl)furan-2-yl)methyl)benzenesulfonamide

Parent CAS No.

[1221277-90-2]

产品资料