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产品名称 AZD 1080
产品货号 Axon 2171 CAS [612487-72-6] MF C19H18N4O2MW 334.37 Purity: 98% Soluble in DMSO Description Potent and selective inhibitor of Glycogen synthase kinase 3 (GSK-3), with Ki values of 6.9 nM and 31 nM for GSK-3α and GSK-3β respectively. In phase 1 clinical studies, AZD 1080 inhibits tau phosphorylation in cells expressing human tau and in intact rat brain. Interestingly, subchronic but not acute administration with AZD 1080 reverses MK-801-induced deficits, measured by long-term potentiation in hippocampal slices and in a cognitive test in mice. References Certificates Categories Extra info B Georgievska et al. AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. J Neurochem. 2013, 125, 446-456.    H Eldar-Finkelman et al. GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS. Front. Mol. Neurosci. 2011, 4, 32..  Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Diabetes & Metabolism Immunology Pain & Inflammation Stem Cell GSK-3 Wnt-β-Catenin PI3K-Akt-mTOR EC 2.7.11.26 Selective inhibitor of GSK-3α and GSK-3β Chemical name 2-Hydroxy-3-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-5-carbonitrile Parent CAS No. [612487-72-6] Order Size Unit Price Stock 5 mg €110.00 In Stock
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AZD 1080

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2171

CAS [612487-72-6]

MF C19H18N4O2
MW 334.37

  • Purity: 98%
  • Soluble in DMSO

AZD 1080

Description

Potent and selective inhibitor of Glycogen synthase kinase 3 (GSK-3), with Ki values of 6.9 nM and 31 nM for GSK-3α and GSK-3β respectively. In phase 1 clinical studies, AZD 1080 inhibits tau phosphorylation in cells expressing human tau and in intact rat brain. Interestingly, subchronic but not acute administration with AZD 1080 reverses MK-801-induced deficits, measured by long-term potentiation in hippocampal slices and in a cognitive test in mice.
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