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产品名称 PTIQ
产品货号 Axon 2328 CAS [1032822-42-6] MF C13H17NO3MW 235.28 Purity: 99% Soluble in 0.1N NaOH(aq), DMSO, and Ethanol Description Brain penetrating neuroprotectant that attenuates MPTP induced motor deficits, prevents neurodegeneration and suppresses microglial activation in the substantia nigra. Mechanistically, PTIQ effectively suppresses expression of MMP-3 (IC50 value 60 nM in stressed dopaminergic cells), and NO production (IC50 value <100 µM in LPS stimulated BV-2 cells). PTIQ also inhibits IL-1β, TNF-α (IC50 value 6.5 µM) and COX-2 (IC50 value 9.3 µM) and blocked nuclear translocation of NF-κB, yet it shows no inhibition of hERG channels or CYP isozyme activities. References Certificates Categories Extra info H.J. Son et al. A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinson's disease induced by MPTP. Br J Pharmacol. 2012 Apr;165(7):2213-27.   J.W. Seo et al. Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells. Eur J Med Chem. 2008 Jun;43(6):1160-70. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cell Signaling & Oncology CNS Miscellaneous Pain & Inflammation EC 3.4.24.17 MMP Neuroprotectant with attenuating effects on MMP-3 expression Chemical name 1-(7-hydroxy-6-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propan-1-one Parent CAS No. [1032822-42-6] Order Size Unit Price Stock 10 mg €125.00 In Stock
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产品品牌 axonmedchem
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PTIQ

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2328

CAS [1032822-42-6]

MF C13H17NO3
MW 235.28

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq), DMSO, and Ethanol

PTIQ

Description

Brain penetrating neuroprotectant that attenuates MPTP induced motor deficits, prevents neurodegeneration and suppresses microglial activation in the substantia nigra. Mechanistically, PTIQ effectively suppresses expression of MMP-3 (IC50 value 60 nM in stressed dopaminergic cells), and NO production (IC50 value <100 µM in LPS stimulated BV-2 cells). PTIQ also inhibits IL-1β, TNF-α (IC50 value 6.5 µM) and COX-2 (IC50 value 9.3 µM) and blocked nuclear translocation of NF-κB, yet it shows no inhibition of hERG channels or CYP isozyme activities.
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