产品名称

GW 2580

产品货号

Axon 2571 CAS [870483-87-7] MF C20H22N4O3MW 366.41 Purity: 99% Soluble in DMSO Description An orally bioavailable inhibitor of c-FMS kinase (IC50 value of 0.03 µM in vitro) and the CSF1R receptor (Kd value 1.6 nM) that competitively blocks the ATP binding site of c-FMS. GW 2580 was inactive against 26 kinases in vitro and did not inhibit the growth of mouse NS0 lymphoblastoid cells, human fibroblasts, human endothelial cells, and five human tumor cell lines. GW 2580 also interacts with TrkA, TrkB, and TrkC (Kd values 630 nM, 36 nM, and 120 nM, respectively) KEYWORDS: GW 2580 | supplier | dual cFMS kinase/CSF1R inhibitor | GW2580 | GW-2580 | CAS [870483-87-7] | FLT3LG | FMS | Inhibitor |RTK| c-FMS| CSF1R | FLT3 | ATP binding site | TrkA | TrkB | TrkC

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

GW 2580

Based on 266 reference(s) in Google Scholar 10 10 266

Axon 2571

CAS [870483-87-7]

MF C20H22N4O3
MW 366.41

Purity: 99%
Soluble in DMSO

GW 2580

Description

An orally bioavailable inhibitor of c-FMS kinase (IC50 value of 0.03 µM in vitro) and the CSF1R receptor (Kd value 1.6 nM) that competitively blocks the ATP binding site of c-FMS. GW 2580 was inactive against 26 kinases in vitro and did not inhibit the growth of mouse NS0 lymphoblastoid cells, human fibroblasts, human endothelial cells, and five human tumor cell lines. GW 2580 also interacts with TrkA, TrkB, and TrkC (Kd values 630 nM, 36 nM, and 120 nM, respectively)