产品名称

FDI 6 - NCGC 00099374

产品货号

Axon 2384 CAS [313380-27-7] MF C19H11F4N3OS2MW 437.43 Purity: 99% Soluble in DMSO Description Inhibitor of the Forkhead box protein M1 transcription factor (IC50 value 22.5 µM for inhibiting FOXM1-DNA binding). FDI6 displaces FOXM1 from genomic targets in MCF-7 breast cancer cells, and induces concomitant transcriptional downregulation. FDI-6 is inactive against the proteasome, and concordance between its biophysical IC50 and cellular GI50 values (22.5 μM and 18.0 μM, respectively) suggests it does not suffer from the off-target effects of thiostrepton. References Certificates Categories Extra info M.V. Gormally et al. Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat Commun. 2014 Nov 12;5:5165. G. Marsico et al. Small molecule inhibition of FOXM1: How to bring a novel compound into genomic context. Genomics Data 3 (2015) 19-23. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Epigenetics Transcription Factors FOXM1 TF class 3.3.1 Inhibitor of the Forkhead box protein M1 (FOXM1) Chemical name 3-amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide Parent CAS No. [313380-27-7] Order Size Unit Price Stock 10 mg €99.00 In Stock

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axonmedchem

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FDI 6 - NCGC 00099374

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2384

CAS [313380-27-7]

MF C19H11F4N3OS2
MW 437.43

Purity: 99%
Soluble in DMSO

FDI 6

Description

Inhibitor of the Forkhead box protein M1 transcription factor (IC50 value 22.5 µM for inhibiting FOXM1-DNA binding). FDI6 displaces FOXM1 from genomic targets in MCF-7 breast cancer cells, and induces concomitant transcriptional downregulation. FDI-6 is inactive against the proteasome, and concordance between its biophysical IC50 and cellular GI50 values (22.5 μM and 18.0 μM, respectively) suggests it does not suffer from the off-target effects of thiostrepton.

M.V. Gormally et al. Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat Commun. 2014 Nov 12;5:5165.

G. Marsico et al. Small molecule inhibition of FOXM1: How to bring a novel compound into genomic context. Genomics Data 3 (2015) 19-23.

Inhibitor of the Forkhead box protein M1 (FOXM1)

Chemical name

3-amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

Parent CAS No.

[313380-27-7]

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