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产品名称 Mps1-IN-2
产品货号 Axon 2358 CAS [1228817-38-6] MF C26H36N6O3MW 480.60 Purity: 98% Soluble in DMSO Description Small-molecule inhibitor of Mps1 kinase (IC50 values 145 nM) with greater than 1000-fold selectivity relative to the 352-member kinase panel, with the major exceptions of Gak and Plk1 (Ambit essay Kd values 12 nM, 140 nM, and 61 nM for Mps1, Gak, and Plk1, respectively). Mps1-IN-2 induces bypass of a checkpoint-mediated mitotic arrest and provides a unique tool to investigate the combined inhibition of Plk1 and Mps1. References Certificates Categories Extra info W. Lan et al. A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J. Cell Biol. 2010, 190, 21-24.   N. Kwiatkowski et al. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat. Chem. Biol. 2010, 6, 359-368. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Stem Cell MPS1 Kinase EC 2.7.11.1 EC 2.7.12.1 GAK PLK Inhibitor of Mps1 kinase with add-on affinity for Gak and Plk1 Chemical name 9-cyclopentyl-2-(2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenylamino)-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one Parent CAS No. [1228817-38-6] Order Size Unit Price Stock 5 mg €95.00 In Stock
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Mps1-IN-2

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2358

CAS [1228817-38-6]

MF C26H36N6O3
MW 480.60

  • Purity: 98%
  • Soluble in DMSO

Mps1-IN-2

Description

Small-molecule inhibitor of Mps1 kinase (IC50 values 145 nM) with greater than 1000-fold selectivity relative to the 352-member kinase panel, with the major exceptions of Gak and Plk1 (Ambit essay Kd values 12 nM, 140 nM, and 61 nM for Mps1, Gak, and Plk1, respectively). Mps1-IN-2 induces bypass of a checkpoint-mediated mitotic arrest and provides a unique tool to investigate the combined inhibition of Plk1 and Mps1.
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