| 产品名称 | Wnt-C59 - C59 |
| 产品货号 | Axon 2287 CAS [1243243-89-1] MF C25H21N3OMW 379.45 Purity: 98% Soluble in DMSO Description Nanomolar and orally available inhibitor of mammalian PORCN acyltransferase activity (IC50 value of 74 pM) that blocks activation of all evaluated human Wnts ( Wnt palmitoylation, Wnt interaction with the carrier protein Wntless/WLS, Wnt secretion, and Wnt activation of β-catenin reporter activity).The tumor growth inhibition of Wnt-C59 in MMTV-WNT1 transgenic mice is associated with decreased Wnt/β-catenin signaling in tumors. References Certificates Categories Extra info K.D. Proffitt et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013, 73, 502-507. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Stem Cell Porcupine Wnt-β-Catenin EC 2.3.1 Stem Cell Differentiator Highly potent porcupine (Porcn) inhibitor Chemical name 2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide Parent CAS No. [1243243-89-1] Order Size Unit Price Stock 2 mg €75.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
Wnt-C59 - C59Axon 2287 CAS [1243243-89-1] MF C25H21N3O
Description
Nanomolar and orally available inhibitor of mammalian PORCN acyltransferase activity (IC50 value of 74 pM) that blocks activation of all evaluated human Wnts ( Wnt palmitoylation, Wnt interaction with the carrier protein Wntless/WLS, Wnt secretion, and Wnt activation of β-catenin reporter activity).The tumor growth inhibition of Wnt-C59 in MMTV-WNT1 transgenic mice is associated with decreased Wnt/β-catenin signaling in tumors.
Highly potent porcupine (Porcn) inhibitor
Chemical name2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide Parent CAS No.[1243243-89-1] |
| 产品资料 |
