产品名称

JQ-1, (+)- - JQ1

产品货号

Axon 1989 CAS [1268524-70-4] MF C23H25ClN4O2SMW 456.99 Purity: 99% Optical purity: 99% ee Soluble in DMSO Description Potent and selective BET bromodomain inhibitor (IC50 values of 77 nM and 33 nM for inhibition of binding of a tetra-acetylated histone H4 peptide to BRD4 with the first and second bromodomain, respectively). (+)-JQ1 is capable of blocking the macrophage inflammatory responses via inhibition of BET proteins in mice, and activating HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. Cotreatment with JQ1 and the FLT3 inhibitor AC220 (Axon 1696) synergistically induce apoptosis of cultured and primary CD34(+) human AML blast progenitor cells (BPC) expressing FLT3-ITD. KEYWORDS: (+)-JQ-1 | BET inhibitor | JQ1 | JQ-1 | JQ1 | CAS [1268524-70-4] | Histone | BET (BRD) | Inhibitor | Proteins | Bromodomain | inflammatory | HIV latency

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

JQ-1, (+)- - JQ1

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1989

CAS [1268524-70-4]

MF C23H25ClN4O2S
MW 456.99

Purity: 99%
Optical purity: 99% ee
Soluble in DMSO

JQ-1, (+)-

Description

Potent and selective BET bromodomain inhibitor (IC50 values of 77 nM and 33 nM for inhibition of binding of a tetra-acetylated histone H4 peptide to BRD4 with the first and second bromodomain, respectively). (+)-JQ1 is capable of blocking the macrophage inflammatory responses via inhibition of BET proteins in mice, and activating HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. Cotreatment with JQ1 and the FLT3 inhibitor AC220 (Axon 1696) synergistically induce apoptosis of cultured and primary CD34(+) human AML blast progenitor cells (BPC) expressing FLT3-ITD.