| 产品名称 | CHR 6494 trifluoroacetate |
| 产品货号 | Axon 2250 CAS [1458630-17-5] MF C16H16N6.C2HF3O2MW 406.36 Purity: 99% Soluble in DMSO Description Specific, first-in-class inhibitor of histone kinase Haspin, which blocks H3T3 phosphorylation in association with a characteristic spindle and centrosome phenotype (IC50 values are 500 nM, 473 nM and 752 nM for apoptosis induction in HCT-116, HeLa and MDA-MB-231 cells, respectively). CHR 6494 causes arrest in G2/M, induces apoptosis and possesses ex vivo anti-angiogenesis features and antitumoral properties in a nude mice xenograft model. Haspin function is critical in mitosis, favouring chromosome cohesion, metaphase alignment and progression through the cell cycle. References Certificates Categories Extra info Huertas, D. et al. Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene (2012), 31(11), 1408-1418. Cuny, Gregory D. et al. Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorg. Med. Chem. Lett. 2012, 22, 2015-2019. Certificate of Analysis Material Safety Data Sheet Angiogenesis Apoptosis Cell Cycle Regulation Cell Signaling & Oncology DNA-damage Response Haspin EC 2.7.11.1 Specific, first-in-class inhibitor of histone kinase Haspin Chemical name 3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate Parent CAS No. [1333377-65-3] Order Size Unit Price Stock 10 mg €120.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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CHR 6494 trifluoroacetateAxon 2250 CAS [1458630-17-5] MF C16H16N6.C2HF3O2
Description
Specific, first-in-class inhibitor of histone kinase Haspin, which blocks H3T3 phosphorylation in association with a characteristic spindle and centrosome phenotype (IC50 values are 500 nM, 473 nM and 752 nM for apoptosis induction in HCT-116, HeLa and MDA-MB-231 cells, respectively). CHR 6494 causes arrest in G2/M, induces apoptosis and possesses ex vivo anti-angiogenesis features and antitumoral properties in a nude mice xenograft model. Haspin function is critical in mitosis, favouring chromosome cohesion, metaphase alignment and progression through the cell cycle.
Specific, first-in-class inhibitor of histone kinase Haspin
Chemical name3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate Parent CAS No.[1333377-65-3] |
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