产品名称

BIBW 2992 - Afatinib

产品货号

Axon 1544 CAS [850140-72-6] MF C24H25ClFN5O3MW 485.94 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Second generation tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal receptor 2 (Her2 or ErbB 2) and EGFR (HER1) kinases. An investigational drug for breast cancer as well as other EGFR and Her2 driven cancers such as NSCLC and Head-and-Neck KEYWORDS: BIBW 2992 | supplier | EGFR/HER2 inhibitor | 850140-72-6 | 439081-18-2 | Afatinib | BIBW2992 | BIBW-2992 | EGFR | ErbB2-HER2 | TKI | breast cancer | epidermal | growft factor

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

BIBW 2992 - Afatinib

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1544

CAS [850140-72-6]

MF C24H25ClFN5O3
MW 485.94

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

BIBW 2992

Description

Second generation tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal receptor 2 (Her2 or ErbB 2) and EGFR (HER1) kinases. An investigational drug for breast cancer as well as other EGFR and Her2 driven cancers such as NSCLC and Head-and-Neck

KEYWORDS: BIBW 2992 | supplier | EGFR/HER2 inhibitor | 850140-72-6 | 439081-18-2 | Afatinib | BIBW2992 | BIBW-2992 | EGFR | ErbB2-HER2 | TKI | breast cancer | epidermal | growft factor

N Minkovsky and A Berezov. BIBW-2992, a dual receptor tyrosine kinase inhibitor for the treatment of solid tumors. Curr. Opin. Investig. Drugs 2008, 9(12), 1336–46.

D Li et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 2008, 27, 4702–4711.

C Campas et al. BIBW-2992. Dual EGFR/HER2 inhibitor, oncolytic. Drugs Fut. 2008, 33(8), 649.

Angiogenesis Cell Signaling & Oncology EGFR ErbB2-HER2 JAK-STAT RTK class I; EC 2.7.10.1

EGFR and ErbB-2/HER2 tyrosine kinase inhibitor

Chemical name

(S,E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Parent CAS No.

[850140-72-6]

产品资料