Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
| Target |
Proteinase 3 |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
ELISA, WB |
| Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Purified recombinant fragment of human Proteinase 3 expressed in E. Coli. |
| Purification |
Purified by Protein G affinity chromatography. |
| Form |
Liquid |
| Isotype |
IgG2b |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
28 kDa |
| Swiss Prot |
P24158
|
| GeneID |
5657
|
| Gene Symbol |
PRTN3 |
| OMIM |
177020
|
| HGNC |
9495 |
| Ensembl |
ENSG00000196415 |
| Concentration |
1.0 mg/ml |
| Buffer |
PBS containing 50% glycerol and 0.03% sodium azide. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |