CD8 T cell surface antigen is heterodimer of an alpha and a beta chain linked by two disulfide bonds.It belongs type I membrane protein. Selectively expressing of CD8 on a subset of T cells leads to CD8 T cell development. Through identifying cytotoxic/suppressor T-cells that interact with MHC class I bearing targets, CD8 is thought to play a role in the process of T-cell mediated killing. Veillette et al (1988) found the CD8 is associated with the internal membrane tyrosine- protein kinase p56lck.
| Target |
CD8 |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
ELISA, FCM |
| Recommended dilutions |
ELISA: 1/10000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Purified recombinant fragment of human CD8 expressed in E. Coli. |
| Purification |
Purified antibody |
| Isotype |
IgG1 |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
25 kDa |
| Swiss Prot |
P01732
|
| GeneID |
925
|
| Gene Symbol |
CD8A |
| OMIM |
186910
|
| HGNC |
1706 |
| Ensembl |
ENSG00000153563 |
| Concentration |
1.0 mg/ml |
| Buffer |
PBS containing 0.03% sodium azide. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |