This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription.The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2.Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone.Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
| Target |
ESR1 |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
ELISA, WB, IHC, IF/ICC |
| Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Purified recombinant fragment of human ESR1 expressed in E. coli. |
| Purification |
Unpurified Ascites. |
| Isotype |
IgG1 |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
66 kDa |
| Swiss Prot |
P03372
|
| GeneID |
2099
|
| Gene Symbol |
ESR1 |
| OMIM |
133430
|
| HGNC |
3467 |
| Ensembl |
ENSG00000091831 |
| Buffer |
Ascitic fluid containing 0.03% sodium azide. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |