GTF2I Antibody is a Rabbit Polyclonal antibody against GTF2I. The GTF2I gene encodes a transcription factor. It negatively regulates agonist-induced calcium entry into cells by interfering with expression of the cation channel TRPC3 at the plasma membrane [PMID: 17023658]. As a transcription factor and/or as a regulator of intracellular calcium levels, GTF2I may play a role in the molecular basis of anxiety[PMID: 22578324]. It interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation [PMID: 16738337].

Target	GTF2I
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Tested Applications	WB, IHC, IF/ICC, FCM
Recommended dilutions	WB: 1/200 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/100, FCM: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Recombinant protein of human GTF2I.
Purification	Affinity purified.
Form	Liquid
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at 2°C to 8°C upon receipt.
Molecular Weight	Calculated MW: 30 kDa/107 kDa/110 kDa/112 kDa Observed MW: 140 kDa
Swiss Prot	P78347
GeneID	2969
Gene Symbol	GTF2I
Concentration	> 1 mg/ml
Buffer	PBS, pH 7.3, 0.02% sodium azide.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.