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| Product Name | Recombinant Mouse IL-23 (carrier-free) |
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| Description | IL-23 is a member of the IL-6 family of cytokines, and it is constituted by two subunits, p19 and p40. The p19-p40 heterodimer is stabilized by a disulfide bond. The subunit p40 is shared by IL-23 and IL-12 cytokines. p19 mRNA is expressed in endothelial cells and polarized T cells; nevertheless, p40 is not expressed by these cells. Therefore, the availability of functional IL-23 is limited by the expression of p40 and not p19. IL-23 exerts its biological activities through the interaction with a heterodimeric receptor complex composed of IL-12Rb1 and IL-23R. IL-23 activates Janus kinase (JAK)/signal transducer and activator of transcription signaling molecules (STAT). JAK2 is constitutively associated with the IL-23R chain, and binding of IL-23 to its receptor leads to phosphorylation of STAT1, STAT3, STAT4, and STAT5. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 16160, 83430 |
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| Catalog # | 589008 |
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| Price | |
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| Order / More Info | Recombinant Mouse IL-23 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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