| 产品详情 |
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| Product Name | Recombinant Bordetella pertussis Pertussis toxin subunit 1 (ptxA) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 28.2kDa. Full Length of Mature Protein: 35-269aa. N-terminal 6xHis-tagged. Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251). S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD+ into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their mbrane receptors. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Islet-activating protein S1; IAP S1NAD-dependent ADP-ribosyltransferase (EC:2.4.2.-) |
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| Gene, Accession, CAS # | ptxA, UniProt: P04977 |
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| Catalog # | RPC25226 |
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| Price | |
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| Order / More Info | Recombinant Bordetella pertussis Pertussis toxin subunit 1 (ptxA) from BIOMATIK |
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| Product Specific References | n/a |
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