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| Antigenic Specificity | CD274 (PD-L1, B7-H1) |
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| Clone | MIH1 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, kappa |
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| Format | unconjugated, functional grade |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1 µg/test, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH1), Functional Grade, eBioscience™. Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion. |
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| Immunogen | n/a |
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| Other Names | B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, B7 homolog 1, CD274 antigen, PDCD1 ligand 1, programmed cell death 1 ligand 1, programmed death ligand 1 |
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| Gene, Accession # | Entrez: 29126; Uniprot: Q9NZQ7 |
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| Catalog # | 16-5983-82 |
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| Price | |
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| Order / More Info | CD274 (PD-L1, B7-H1) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 15837746, 16282703, 16954372, 18296654, 18791172, 19246340, 19264916, 19380770, 19635905, 20123111, 20460501, 20819923, 20886079, 21349174, 21355078, 21625589, 21750202, 21795591, 21816363, 22661084, 22829769, 23391724, 23585913, 24708420, 24741578, 24885059, 24894091, 25073001, 25120686, 25202350, 25472998, 25780040, 25902191, 25979485, 26236467, 26260996, 26321145, 26657115, 26847035, 27128502, 27314219, 27350882, 27467927, 27574444, 27671847, 28233730, 28325288, 28903377, 29246442, 29409495, 29593314, 29668679 |
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