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| Antigenic Specificity | Aph-1a, 245-265 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Western Blot (WB), Immunofluorescence Microscopy (IF) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-Aph-1a, 245-265 (C terminus). The gamma secretase is a multiprotein complex consisting of presenilin, nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic activity. The gamma secretase complex catalyzes cleavage of a number of integral membrane proteins including Amyloid precursor protein, Notch, Erb4 and E-cadherin. While Aph-1 stabilizes the presenilin holoprotein within the gamma secretase complex, Pen-2 is required for endoproteolysis of presenilin and activation of the gamma secretase. The Aph-1 homologue on human chromosome 1 is termed Aph-1a and on human chromosome 15 is referred to as Aph-1b. |
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| Immunogen | The antibody Aph-1a, 245-265 (Poly18231) was raised against the human Aph-1aL/C-terminal region and recognizes the sequence CRRQEDSRVMVYSALRIPPED of human Aph-1aL. |
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| Other Names | Gamma-secretase subunit APH-1A, aph-1alpha, presenilin-stabilization factor, CGI-78, anterior pharynx defective 1 homolog A, presenilin-stabilization factor, PRB-550P-100 |
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| Gene, Accession # | Gene ID: 51107 |
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| Catalog # | 823101 |
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| Price | |
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| Order / More Info | Aph-1a, 245-265 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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