| 产品详情 |
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| Antigenic Specificity | Bcl11b |
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| Clone | 25B6 |
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| Host Species | Rat |
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| Reactive Species | human, cross-reactive: mouse, zebrafish |
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| Isotype | IgG2a, κ |
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| Format | purified |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), ICC, ChIP, IHC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-Bcl11b. The transcription factor Bcl11b is expressed in thymus, mainly T cells. It is indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies. |
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| Immunogen | Human Bcl11b |
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| Other Names | B-cell CLL/lymphoma 11B (zinc finger protein), CTIP2, B-cell lymphoma/leukemia 11B |
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| Gene, Accession # | Gene ID: 64919 |
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| Catalog # | 650601 |
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| Price | |
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| Order / More Info | Bcl11b Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 23671688 |
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| 产品资料 |
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