| 产品详情 |
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| Antigenic Specificity | CARD9 |
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| Clone | 13D9C60 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG2a, κ |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), ICC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-CARD9. Caspase recruitment domain-containing protein 9 (CARD9) is a member of the CARD protein family, which is known to play regulatory roles in cell apoptosis. CARD9 is an adaptor protein that mediates the signaling downstream of C-type lectin receptors (CLRs), such as Dectin-1, Dectin-2, and Mincle. CARD9 also participates in the signaling downstream of the Retinoic acid-inducible gene I receptor (RIG-1) family. After stimulation of the receptors, CARD9 is phosphorylated and forms a trimolecular complex with B cell leukemia-lymphoma 10 (Bcl10) and mucosa-associated lymphoid tissue 1 (Malt1), which activates the canonical NF-κB pathway and leads to the induction of proimflammatory cytokines, including IL-6, IL-1β, and tumor necrosis factors-alpha (TNFs). CARD9 has been suggested to play an important role in antifungal host defense, as the CARD9 deficient mice are more susceptible to pathogenic fungi infections. |
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| Immunogen | Human CARD9 peptide (LRKMQKGWRQGEEDRENT) conjugated to KLH. |
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| Other Names | Caspase Recruitment Domain-Containing Protein 9, CANDF2, hCARD9 |
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| Gene, Accession # | Gene ID: 64170 |
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| Catalog # | 679102 |
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| Price | |
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| Order / More Info | CARD9 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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