| 产品详情 |
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| Antigenic Specificity | CYLD |
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| Clone | 733 |
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| Host Species | Mouse |
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| Reactive Species | bovine, equine, human, mouse, nonhuman primate, rat |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1 µg/mL, Immunofluorescence: 1 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: Assay Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CYLD Monoclonal Antibody (733). CYLD is a 956 aa, cytoplasmic, deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family of proteins with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains, a proline rich region, a SH3 binding domain and a sequence homology to catalytic domain of UCH. CYLD is identified as a tumor suppressor protein affecting the JNK signaling pathway. CYLD is a negative regulator of TRAF2 and NF-kappa-B signaling pathway and is also known to have receptor-dependent role in regulating the I-kappa-B kinase pathway. It also has a deubiquitinating activity that is directed towards non-Lys-48-linked polyubiquitin chains and TRAP1 is a novel substrate for deubiquitination. |
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| Immunogen | n/a |
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| Other Names | BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2 |
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| Gene, Accession # | Entrez: 100050308, 1540, 312937, 536421, 74256; Uniprot: Q1RMU2, Q66H62, Q80TQ2, Q9NQC7 |
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| Catalog # | 43-7700 |
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| Price | |
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| Order / More Info | CYLD Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 25093162, 25316792 |
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