| 产品详情 |
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| Product Name | AZD-9291 mesylate |
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| Description | AZD9291 is a potent, selective, and irreversible, third generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). It inhibits EGFR phosphorylation in EGFR-bearing cells harboring sensitizing EGFR mutants with mean IC50 values ranging from 13 to 54 nM. It also potently inhibits phosphorylation of EGFR in T790M+ mutant cell lines. AZD-9291 displays profound and sustained tumor regression in EGFR-mutant tumor xenograft and transgenic models. MW: 595.71. Purity ≥98% by HPLC |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (Z)-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylimidic acid methnanesulfonic acid; Osimertinib, methanesulfonate |
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| Gene, Accession, CAS # | CAS: 1421373-66-1 |
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| Catalog # | B1899-25 |
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| Order / More Info | AZD-9291 mesylate from BIOVISION, INC. |
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| Product Specific References | n/a |
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