| 产品详情 |
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| Antigenic Specificity | IL-18 |
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| Clone | KU18-81 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgM |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-human IL-18. IL-18, initially described as IFN-g inducing factor (IGIF), is a pro-inflammatory cytokine. It is an 18-kD cytokine which identified as a costimulatory factor for production of interferon-γ (IFN-γ) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24-kD molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. The cytokine IL-18 possesses pleiotropic biological properties such as activation of NF-kb, Fas ligand expression, induction of both CC and CXC chemokines, enhancement of the production of IFN-g and GM-CSF, and induction of CD4+ cytolytic T cell response. Its role in neurodegeneartion disease has also been reported. |
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| Immunogen | Recombinant protein |
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| Other Names | IL-1 gamma, IFN-gamma-inducing factor, IL1F4 |
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| Gene, Accession # | Gene ID: 3606 |
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| Catalog # | 517302 |
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| Price | |
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| Order / More Info | IL-18 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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