| 产品详情 |
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| Antigenic Specificity | Ikaros |
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| Clone | 2A9/Ikaros |
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| Host Species | Mouse |
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| Reactive Species | mouse |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), Immunofluorescence Microscopy (IF), IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-mouse Ikaros. Ikaros family members, including Ikaros and Helios, play a role in the development of lymphocytes and B and T cells. They are nuclear factors that colocalize with DNA replication machinery components in higher-order chromatin structures and respond to signaling events, such as T cell activation. Helios and Ikaros bind to similar DNA sequences, and they function as hemopoietic-specific transcription factors. Members of the Ikaros family contain zinc-finger domains that are involved in DNA-binding and in the formation of homodimers and heterodimers between Ikaros family members. Expression of Ikaros is primarily detected in the thymus and spleen, where it is essential for regulating T cell specific gene transcription and for the differentiation and commitment of early hemopoietic progenitors to the B and T lymphoid lineages. Ikaros and Helios also appear to regulate cell cycle entry by inducing transcriptional repression under varying conditions and, thereby, mediate T cell activation and IL-2 mediated signaling events. |
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| Immunogen | N-terminal half of mouse Ikaros fused to GST. |
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| Other Names | IKAROS family zinc finger 1, DNA-binding protein Ikaros |
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| Gene, Accession # | Gene ID: 22778 |
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| Catalog # | 653302 |
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| Price | |
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| Order / More Info | Ikaros Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 产品资料 |
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