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| Antigenic Specificity | P30 and pro-caspases of p38 and p43 |
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| Clone | Cas11.17D9 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-Caspase-11. Murine caspase-11 is an upstream protease of caspase-1 and interacts with the proform of caspase-1 which in turn activates IL-1 beta. Caspase-11 is not constitutively expressed in most cell types. Its expression can be upregulated by LPS, IFN-gamma, and other pro-inflammatory stimuli. NF-κB and STAT1 were reported to be involved in the activation. Caspase-11 knock -out mice were resistant to endotoxin shock and do not produce IL-1 after stimulation with LPS. Their production of IFN-gamma was also deficient. |
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| Immunogen | His tagged bacterial fusion protein of p 30 of caspase 11 |
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| Other Names | Casp11 |
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| Gene, Accession # | Gene ID: 201161 |
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| Catalog # | 647202 |
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| Price | |
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| Order / More Info | P30 and pro-caspases of p38 and p43 Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 23028835 |
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