| 产品详情 |
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| Antigenic Specificity | FOXO3 |
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| Clone | W15111A |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG2a, κ |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), KO/KD-Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-FOXO3. The Fork-head box O (FOXO) family of transcription factors is comprised of four family members; FOXO1, FOXO3, FOXO4, and FOXO6. FOXO3 was originally identified as a tumor suppressor and has been shown to regulate several cellular processes, such as cell cycle arrest, apoptosis, autophagy, longevity, and stress response. FOXO3 activity is determined by its post-translational modifications and subcellular localization. FOXO3 is inactivated by cytoplasmic retension through AKT/PI3K signaling pathways. FOXO3 inactivation has been associated with cell proliferation and tumorigenesis. In contrast, over-expression of FOXO3 leads to inhibition of tumor growth. FOXO3 also plays an important role in the development of regulatory T cells. FOXO3-deficient mice showed organ inflammation phenotype and increased production of proinflammatory cytokines during viral infection. |
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| Immunogen | Human FOXO3 recombinant protein (424-673 a.a.) expressed in E. coli. |
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| Other Names | Forkhead box O3, FKHRL1, FOXO3A |
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| Gene, Accession # | Gene ID: 2309 |
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| Catalog # | 686302 |
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| Price | |
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| Order / More Info | FOXO3 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 产品资料 |
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