| 产品详情 |
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| Product Name | ABC294640 |
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| Description | A selective inhibitor of SPHK2 (Ki = 9.8 µM); inhibits SPHK2 in a dose-dependent manner (IC50 = 60 µM) without affecting SPHK1 activity at concentrations up to 100 µM; decreases [3H]S1P production in MDA-MB-231 cells in a dose-dependent manner; inhibits proliferation of human tumor cell lines (IC50s = 6-48 µM); reduces A-498 cell migration via reduction of actin filament polymerization; reduces growth of mammary adenocarcinoma xenografts in mice in a dose-dependent manner; attenuates progression of TNBS-induced inflammatory bowel disease in mice and rats |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ABC-294640 SPHK-2 1 MDAMB231 HT29 A498 opaganib 3H-S1P IBD |
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| Gene, Accession, CAS # | CAS: 915385-81-8 |
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| Catalog # | 10587-25 |
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| Price | |
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| Order / More Info | ABC294640 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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