| 产品详情 |
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| Product Name | PRT 4165 |
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| Description | Inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1); inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α (Top2α). Also shown to inhibit the in vitro E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex, inhibiting H2A/H2AX ubiquitination. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo. Purity 99%. MW (observed): 235.24 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione |
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| Gene, Accession, CAS # | CAS: 31083-55-3 |
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| Catalog # | 5047/10 |
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| Order / More Info | PRT 4165 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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