| 产品详情 |
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| Antigenic Specificity | IL-17A |
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| Clone | TC11-18H10.1 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG1, κ |
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| Format | Alexa Fluor® 647 conjugate |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | Intracellular Staining for Flow Cytometry (ICFC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Alexa Fluor® 647 anti-mouse IL-17A. IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course. |
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| Immunogen | E. coli expressed, recombinant mouse IL-17A |
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| Other Names | Interleukin-17A, CTLA-8 |
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| Gene, Accession # | Gene ID: 16171 |
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| Catalog # | 506911 |
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| Price | |
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| Order / More Info | IL-17A Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 17549733,18496841,18606690,19129757,19458338,21949021,22808256,24039898 |
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