| 产品详情 |
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| Antigenic Specificity | IL-17A |
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| Clone | BL168 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, κ |
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| Format | APC-Cyanine7 conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | Intracellular Staining for Flow Cytometry (ICFC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | APC/Cyanine7 anti-human IL-17A. IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively. |
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| Immunogen | Recombinant full length human IL-17A |
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| Other Names | Interleukin IL-17A |
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| Gene, Accession # | Gene ID: 3605 |
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| Catalog # | 512320 |
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| Price | |
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| Order / More Info | IL-17A Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 25405480 |
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| 产品资料 |
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