| Edit |   |
|---|
| Antigenic Specificity | Notch 2 |
|---|
| Clone | HMN2-35 |
|---|
| Host Species | Armenian Hamster |
|---|
| Reactive Species | mouse |
|---|
| Isotype | IgG |
|---|
| Format | phycoerythrin (PE) conjugate |
|---|
| Size | 50 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Flow Cytometry (FC) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | PE anti-mouse Notch 2. The Notch receptors are highly conserved from invertebrates to mammals.While Notch1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences.The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus.This translocation triggers a series of signaling process.Notch 3 is primarily expressed in adult arterial smooth muscle cells.Notch 3 gene mutation can cause CADASIL, an inherited early stroke syndrome. |
|---|
| Immunogen | Notch 2-Fc fusion protein |
|---|
| Other Names | Neurogenic locus notch homolog protein 2, Notch-2, Notch2, AGS2; hN2 |
|---|
| Gene, Accession # | Gene ID: 18129 |
|---|
| Catalog # | 130707 |
|---|
| Price | |
|---|
| Order / More Info | Notch 2 Antibody from BIOLEGEND |
|---|
| Product Specific References | PubMed: 24323359 |
|---|