| 产品详情 |
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| Antigenic Specificity | Notch 3 |
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| Clone | MHN3-21 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-human Notch 3. The Notch receptors are highly conserved from invertebrates to mammals. While Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences. The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus. This translocation triggers a series of signaling processes. Notch 3 is primarily expressed in adult arterial smooth muscle cells. Notch3 gene mutation can cause CADASIL, a hereditary early stroke syndrome. |
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| Immunogen | Human Notch 3-human IgG1 Fc fusion protein |
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| Other Names | Neurogenic locus notch homolog protein 3, Notch-3,CADASIL |
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| Gene, Accession # | Gene ID: 4854 |
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| Catalog # | 345401 |
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| Price | |
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| Order / More Info | Notch 3 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 产品资料 |
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