| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | IL-27 |
|---|
| Clone | MM27-7B1 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | mouse |
|---|
| Isotype | IgG2a |
|---|
| Format | purified |
|---|
| Size | 50 µg |
|---|
| Concentration | n/a |
|---|
| Applications | ELISA Capture |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Purified anti-mouse IL-27 p28. IL-27 is a heterodimeric cytokine consisting of EBV-induced gene-3 (EBI3, an IL-12 p40-related protein) and p28 (a newly discovered IL-12 P35-related protein). It is a member of the IL-6/IL-12 cytokine family and mainly produced by antigen-presenting cells, including macrophages and dendritic cells. IL-27 acts on T cells and NK cells. It has been reported that IL-27 drives rapid clonal expansion of naïve CD4+ T cells, and promotes Th1 polarization and IFN-γ production in synergy with IL-12. The IL-27-induced Th1 differentiation was mediated by rapid and marked upregulation of ICAM-1/LFA-1 interaction in a STAT1-dependent manner. IL-27 exhibits anti-inflammatory function by enhancing Th1 cell differentiation, a potent antitumor activity, through CD8+ T cell and NK cell activation. It also plays a potential therapeutic role in autoimmune disease by inhibiting Th-17 development. IL-27 mediates its biological effects through its receptor, WSX-1/T cell cytokine receptor (TCCR), which is homologous to the IL-12Rβ2 subunit. Protein gp130 serves as a functional signal-transducing molecule for IL-27. |
|---|
| Immunogen | Mouse IL-27-OVA |
|---|
| Other Names | Interleukin-27 p28, IL-27-A, IL-27 subunit alp |
|---|
| Gene, Accession # | Gene ID: 246779 |
|---|
| Catalog # | 516901 |
|---|
| Price | |
|---|
| Order / More Info | IL-27 Antibody from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|