| 产品详情 |
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| Antigenic Specificity | Syk |
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| Clone | 12E3 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:100, Immunofluorescence: 1:100, Immunoprecipitation: 2 µL, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Syk Monoclonal Antibody (12E3). Syk, Spleen tyrosine kinase, is expressed in a wide range of hematopoietic and non-hematopoietic cells and plays a key role in adaptive immune system, which is the immunoreceptor (B cell receptor and Fc-receptors) signaling pathways including Fcgamma receptor-mediated phagocytosis. In hematopoietic cells such as B and T lymphocytes, natural killer cells, mast cells, macrophages and platelets, Syk is involved in the proximal signaling downstream of activated immunoreceptors (e.g. BCR, TCR, Fc receptors) containing immunoreceptor tyrosine-based activation motifs (ITAMs) to which it binds using its tandem SH2 domains. Activated and autophosphorylated Syk then phosphorylates its specific substrates including othe |
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| Immunogen | n/a |
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| Other Names | Tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-syk |
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| Gene, Accession # | Entrez: 6850; Uniprot: P43405 |
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| Catalog # | MA5-17207 |
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| Price | |
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| Order / More Info | Syk Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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