| 产品详情 |
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| Product Name | Recombinant Human Nephrocystin-1 (NPHP1), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 39.7kDa. Partial: 1-109aa. N-terminal GST-tagged. Homo sapiens (Human). Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8. Does not se to be strictly required for ciliogenesis. Ses to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assbly. Required for normal retina development. In connecting photoreceptor cilia influences the movent of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Juvenile nephronophthisis 1 protein |
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| Gene, Accession, CAS # | NPHP1, UniProt: O15259 |
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| Catalog # | RPC21747 |
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| Price | |
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| Order / More Info | Recombinant Human Nephrocystin-1 (NPHP1), partial from BIOMATIK |
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| Product Specific References | n/a |
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