| 产品详情 |
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| Antigenic Specificity | Ly-49A |
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| Clone | YE1/48.10.6 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2a, κ |
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| Format | fluorescein (FITC) conjugate |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | FITC anti-mouse Ly-49A. Ly-49A is a 44 kD member of the C-type lectin/Ly-49 family proteins. It is a type-II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Ly-49A is present on a subset of NK and NK-T cells. Ly-49A, like other members of this family, inhibits NK cell activation through the recognition and interaction of certain MHC class I haplotypes on potential target cells. The Ly-49A receptor recognizes H-2Dd and H-2Dk, triggering phosphorylation of the ITIM motif in the cytoplasmic domain and recruitment of SHP-1 and SHP-2. The YE1/48.10.6 antibody reacts with NK cells from all mouse strains tested and reverses the inhibition of NK cytotoxicity. |
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| Immunogen | Con A activated splenic T cells |
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| Other Names | C-type lectin, Ly-49, ITIM, 44 kD |
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| Gene, Accession # | Gene ID: 16627 |
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| Catalog # | 116805 |
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| Price | |
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| Order / More Info | Ly-49A Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 25385825 |
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