| 产品详情 |
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| Antigenic Specificity | ARHGEF17 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunofluorescence: 20 µg/mL, Immunohistochemistry: 2.5 µg/mL, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ARHGEF17 Polyclonal Antibody. Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically. |
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| Immunogen | n/a |
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| Other Names | P164RHOGEF, TEM4, p164-RhoGEF; 164 kDa Rho-specific guanine-nucleotide exchange factor; Rho-specific guanine-nucleotide exchange factor 164 kDa; rho guanine nucleotide exchange factor 17; tumor endothelial marker 4 |
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| Gene, Accession # | Entrez: 9828; Uniprot: Q96PE2 |
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| Catalog # | PA5-20440 |
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| Price | |
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| Order / More Info | ARHGEF17 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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