| 产品详情 |
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| Antigenic Specificity | ARHGEF18 |
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| Clone | OTI6D10 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:500, Western Blot: 1:500-1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ARHGEF18 Monoclonal Antibody (OTI6D10). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). |
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| Immunogen | n/a |
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| Other Names | P114-RhoGEF, 114 kDa Rho-specific guanine nucleotide exchange factor, P114-RHO-GEF, Rho-specific guanine nucleotide exchange factor p114, Rho/Rac guanine nucleotide exchange factor 18, SA-RhoGEF, p114RhoGEF, rho guanine nucleotide exchange factor 18, septin-associated RhoGEF |
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| Gene, Accession # | Entrez: 23370; Uniprot: Q6ZSZ5 |
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| Catalog # | MA5-27295 |
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| Price | |
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| Order / More Info | ARHGEF18 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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