| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | CD41/CD61 |
|---|
| Clone | PAC-1 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgM, κ |
|---|
| Format | Alexa Fluor® 647 conjugate |
|---|
| Size | 25 tests |
|---|
| Concentration | n/a |
|---|
| Applications | Flow Cytometry (FC) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Alexa Fluor® 647 anti-human CD41/CD61. The gpIIb/IIIa complex, also known as integrin αIIbβ3, is expressed by megakaryocytes and platelets. It undergoes conformational changes upon activation by substances, such as ADP, thrombin, and TXA2, which subsequently reveals a ligand binding site that is specific for fibrinogen, von Willebrand factor (vWF), fibronectin, and vitronectin. This conformational change is crucial for platelet-platelet adhesion. Ligand bound gpIIb/IIIa complex promotes platelet aggregation. This complex plays an important role in hemostasis and is a target for developing therapeutic antibodies in immune thrombocytopenia. |
|---|
| Immunogen | Human platelets |
|---|
| Other Names | glycoprotein IIb/IIIa complex, gpIIb/IIIa complex, integrin αIIbβ3 |
|---|
| Gene, Accession # | Gene ID: 3674, 3690 |
|---|
| Catalog # | 362805 |
|---|
| Price | |
|---|
| Order / More Info | CD41/CD61 Antibody from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|