| 产品详情 |
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| Product Name | AMG 853 |
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| Description | Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist (IC50 values are 8 and 35 nM, respectively in plasma). Inhibits PGD2-induced down modulation of CRTH2 on CD16- granulocytes in human whole blood as well as PGD2-induced cAMP response in platelets. Inhibits PGD2-induced airway constriction in vivo. Also inhibits BRD4 (Kd = 170 nM). Orally bioavailable. Purity 98%. MW (observed): 609.49 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-Chloro-4-[2-[[(2-chloro-4-cyclopropylphenyl)sulfonyl]amino]-4-[[(1,1-dimethylethyl)amino]carbonyl]phenoxy]-2-fluorobenzeneacetic acid |
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| Gene, Accession, CAS # | CAS: 1169483-24-2 |
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| Catalog # | 5701/10 |
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| Price | |
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| Order / More Info | AMG 853 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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