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| Product Name | uPK3A, 19-207aa, Human, His tag, E.coli |
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| Description | Purity: > 90% by SDS - PAGE Format: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% glycerol, 150mM NaCl. uPK3A belongs to the uroplakin-3 family. uroplakins (uP) are key components of the urothelium. They are transmembrane proteins that pass the lipid bilayer once (uPII, uPIIIa, and uPIIIb) or four times (uPIa and uPIb; both belonging to the 'tetraspanin' family). All have large luminal/extracellular domains, but only uPIIIa and uPIIIb have significant cytoplasmic portions in their C-termini. uPK3A is a highly specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Mutations in this gene may be associated with renal adysplasia Recombinant human uPK3A protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. |
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| Size | 250ug, 50ug, 10ug |
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| Concentration | n/a |
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| Applications | SDS-PAGE |
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| Other Names | uroplakin-3a, uPK3 |
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| Gene, Accession, CAS # | BAA31460 |
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| Catalog # | ATGP1304 |
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| Order / More Info | uPK3A, 19-207aa, Human, His tag, E.coli from ATGen |
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| Product Specific References | n/a |
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