| 产品详情 |
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| Antigenic Specificity | CD278 (ICOS) |
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| Clone | 7E.17G9 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2b, κ |
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| Format | purified, azide-free |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC), Block |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LEAF™ Purified anti-mouse CD278 (ICOS). The 7E.17G9 antibody reacts with the 47-57 kD ICOS protein, also known as inducible costimulatory molecule, and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes and can costimulate T cells and induce proliferation. In addition ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand, B7h/B7RP-1 and B7-H2 is constitutively expressed in B cell areas of secondary lymphoid organs and can be induced in other tissues by LPS. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. ICOS stimulation has been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation. |
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| Immunogen | Mouse ICOS cDNA and ICOS hexahistidine fusion protein |
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| Other Names | Inducible COStimulatory molecule, H4 |
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| Gene, Accession # | Gene ID: 54167 |
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| Catalog # | 117408 |
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| Price | |
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| Order / More Info | CD278 (ICOS) Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 16493044 |
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