| 产品详情 |
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| Product Name | PF-543 |
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| Description | A potent inhibitor of SPHK1 (IC50 = 2 nM); inhibits S1P binding to human recombinant SPHK1 (Ki = 3.6 nM); selective for SPHK1 over SPHK2 (IC50 = 356 nM) as well as a panel of protein and lipid kinases and S1P receptors at 10 µM; inhibits the formation of S1P in 1483 cells and human whole blood (EC50s = 8.4 and 26.7 nM, respectively); prevents sickling, hemolysis, and inflammation in a transgenic mouse model of sickle cell disease |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1415562-83-2 biochemical inhibitor kinase protein signal transduction intracellular signaling cancer vascular disease inhibit inhibition PF543 PF 543 SK1 SK2 sphingosine lipid receptor phosphorylation cell blood sickle sickling hemolysis inflammation |
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| Gene, Accession, CAS # | CAS: 1415562-82-1 |
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| Catalog # | 17034-1 |
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| Price | |
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| Order / More Info | PF-543 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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