| 产品详情 |
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| Product Name | PD 123319 (trifluoroacetate salt) |
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| Description | Purity >98%. Angiotensin II is a peptide hormone that regulates blood pressure and fluid balance, contributing to hypertension, atherosclerosis, left ventricular hypertrophy, myocardial infarction, and heart failure. It binds with high affinity to two distinct receptors: AT1 R (angiotensin type 1 receptor) and AT2 R (angiotensin type 2 receptor). AT1 R activation facilitates the 'classical' effects, including vasoconstriction, cellular growth, and proliferation, whereas AT2 R activation offsets AT1 R-mediated actions, promoting vasodilatation, apoptosis, and anti-growth effects. PD 123319 is a selective, nonpeptide AT2 R antagonist (IC50 = 5.6 nM vs. 100 nM for AT1 R). It has been used to selectively examine the specific roles for AT1 R and AT2 R in hypertensive and other vascular research-related models. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (6S)-1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid, di(2,2,2-trifluoroacetate) |
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| Gene, Accession, CAS # | CAS: 136676-91-0 |
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| Catalog # | LS-H9291 |
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| Price | |
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| Order / More Info | PD 123319 (trifluoroacetate salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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