| 产品详情 |
| Edit |   |
|---|
| Product Name | EGLN3, 1-239aa, Human, His tag, E Coli |
|---|
| Description | MW: 29.8 kDa (263aa) confirmed by MALDI-TOF. EGLN3, a member of the EGLN family of prolyl hydroxylases, has been shown to catalyze hydroxylation of the alpha subunit of hypoxia-inducible factor-alpha, which targets hypoxia-inducible factor-alpha for ubiquitination by a ubiquitin ligase complex containing the von Hippel-Lindau (VHL) tumor suppressor. EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM2 in hypoxia, |
|---|
| Size | 0.02 mg, 0.1 mg |
|---|
| Concentration | 0.25 mg/ml (determined by Bradford assay) |
|---|
| Applications | SDS-PAGE |
|---|
| Other Names | [Egl nine homolog 3; HIFPH3; PHD3] |
|---|
| Gene, Accession, CAS # | EGLN3, Gene ID: 112399, Accession: NP_071356 |
|---|
| Catalog # | MBS204581 |
|---|
| Price | |
|---|
| Order / More Info | EGLN3, 1-239aa, Human, His tag, E Coli from MYBIOSOURCE INC. |
|---|
| Product Specific References | Epstein A.C.R., et al. (2001) Cell. 107:43-54; Lee S., et al. (2000) Cancer Cell. 8:155-167 |
|---|
| 产品资料 |
|
|