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| Antigenic Specificity | CD274 (PD-L1, B7-H1) |
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| Clone | MIH5 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2a, lambda |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 0.25 µg/test, Functional Assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Neutralization: Assay-Dependent, Western Blot: Assay-Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH5), eBioscience™. Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion. |
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| Immunogen | n/a |
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| Other Names | B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, B7 homolog 1, CD274 antigen, PDCD1 ligand 1, programmed cell death 1 ligand 1, programmed death ligand 1 |
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| Gene, Accession # | Entrez: 60533; Uniprot: Q9EP73 |
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| Catalog # | 14-5982-82 |
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| Price | |
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| Order / More Info | CD274 (PD-L1, B7-H1) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 15758163, 17785507, 18354211, 18593946, 18607390, 18621049, 19734905, 20048044, 20049875, 20530875, 20574047, 20628373, 20653631, 21494618, 21816363, 21873557, 22003106, 22110693, 22745325, 22891289, 23460643, 23556020, 23616570, 23817617, 23997225, 24015822, 24067957, 24247196, 24324295, 24336068, 24550187, 24677019, 24890099, 25080485, 25086067, 25113973, 25156126, 25157219, 25311657, 25415283, 25630305, 26026061, 26041735, 26519533, 26910562, 27156385, 27402485, 27406624, 27610613, 27657168, 28096382, 28436428, 29246442, 29593314 |
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